Endocrine Abstracts

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. ...

Introduction: Pituitary surgery is currently considered the preferred treatment for Cushing’s disease (CD) and achieves remission in 55–85% of patients. Cortisol falls quickly after surgery, so that early post-operative cortisol level has been used as predictor of remission. There’s no agreement about optimal timing for cortisol measurement, with wide variability between centres.Objective: To assess the value of early post-operative serum ...

Introduction: Cushing’s disease (CD) is characterised by pathologic hypercortisolism caused by an ACTH-secreting pituitary adenoma. The primary modality for definitive treatment is pituitary surgery. The rarity of CD has made it difficult to establish reliable predictive factors of outcomes.Aim: Assessment of clinical, hormonal, radiological, surgical and histological findings as predictors of remission and relapse of CD.Metho...

Background: Community acquired pneumonia (CAP) is a common condition and a major cause of morbidity. Diabetes mellitus (DM) increases the risk and complications of infectious diseases. However, it is necessary to clarify if DM and glycemia at the time of presentation are prognostic factors in patients with CAP.Objectives: To evaluate the relationship between DM/glycemia at the time of presentation and complications, length of stay and mortality in patien...

Introduction: Madelung’s disease is a rare disorder characterized by a disturbance in the adipocyte metabolism. Mainly occurs in alcoholic Mediterranean male, presenting multiple, symmetrical lipomas.Case report: A 49-year-old obese man with a history of alcoholism, complaint of weight gain, soft and slow-growing swelling of the neck, and shoulders. His past history: epilepsy, alcoholic CHD, hypothyroidism, severe sleep apnea, vitiligo and HTA. His ...

Introduction: Differentiated thyroid cancer (DTC) is rare in the paediatric population when compared to adults. Paediatric patients often present with advanced disease at diagnosis, characterized by multifocal disease, heightened lymph node involvement, and distant metastasis. Additionally, they face a higher risk of post-operative complications in comparison to adults. Despite that, paediatric DTC exhibits an excellent prognosis.Methods: A retrospective...

Introduction: Adrenocortical carcinoma is a rare type of cancer that usually has a dismal prognosis. The concurrent hormonal excess of some of these tumours can have an additional negative impact on patients´ morbidity and mortality.Clinical Case: We present the case of a 57-year-old woman diagnosed with stage IV adrenocortical carcinoma, with liver and bone metastasis, and associated ACTH-independent Cushing syndrome and hyperandrogenism. The patie...

Introduction: Pancreatic neuroendocrine tumors (PNETs) originate from neuroendocrine islet cells and can therefore secrete several neuropeptides. Multiple and secondary hormone secretion have been described in a minority of cases, mostly with advanced disease, and it has been hypothesized that this complex secretion pattern can serve as a marker for tumor behavior.Case report: Male patient, 69 years old, diagnosed with a glucagonoma with pulmonary and he...

Background: Nivolumab is a monoclonal antibody specific for human PD-1 (programmed cell death protein-1), a checkpoint molecule highly expressed in several cancers. Nivolumab is an immunotherapeutic strategy for human cancer, but it can interfere with endocrine system.Case reports: We report four cases regarding nivolumab-associated endocrinopathies: (i) Male, 55-year-old, with previous normal cortisol and adrenocorticotropic hormone (ACTH) levels, treat...